From recent abstract
Long-term moderate magnesium-deficient diet shows relationships
between blood pressure, inflammation and oxidant stress defense in
aging rats.
* Blache D,
* Devaux S,
* Joubert O,
* Loreau N,
* Schneider M,
* Durand P,
* Prost M,
* Gaume V,
* Adrian M,
* Laurant P,
* Berthelot A.
INSERM U 498, Biochimie des Lipoproteines, Dijon, F-21079, France;
Faculte de Medecine, Universite de Bourgogne, Dijon, F-21079, France.
Epidemiological and experimental studies have indicated a relationship
among aging, dietary Mg, inflammatory stress, and cardiovascular
disease. Our aim in the present study was to investigate possible
links between dietary Mg, oxidant stress parameters, and inflammatory
status with aging in rats. We designed a long-term study in which rats
were fed for 22 months with moderately deficient (150 mg/kg), standard
(800 mg/kg), or supplemented (3200 mg/kg) Mg diets. Comparisons were
made with young rats fed with the same diets for 1 month. Compared to
the standard and supplemented diets, the Mg-deficient diet
significantly increased blood pressure, plasma interleukin-6,
fibrinogen, and erythrocyte lysophosphatidylcholine, particularly in
aging rats, it decreased plasma albumin. The impairment of redox
status was indicated by increases in plasma thiobarbituric acid
reactive substances and oxysterols and an increased blood
susceptibility to in vitro free-radical-induced hemolysis. We
concluded that Mg deficiency induced a chronic impairment of redox
status associated with inflammation which could significantly
contribute to increased oxidized lipids and promote hypertension and
vascular disorders with aging. Extrapolating to the human situation
and given that Mg deficiency has been reported to be surprisingly
common, particularly in the elderly, Mg supplementation might be
useful as an adjuvant therapy in preventing cardiovascular disease.
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