A study of 1,000 people found that staying active nearly halved the odds of catching cold viruses and, failing that, made the infection less severe.
Experts told the British Journal of Sports Medicine that this could be because exercise helps bolster the immune system to fight off bugs.
But you may not have to actually do much exercise - those who merely think they are fit enjoy the same lower risk.
Adults can expect to suffer two to five colds per year. This latest research suggests there are lifestyle choices you can make to improve your odds of either avoiding them, or suffering too badly from them.
The volunteers were also asked to say how frequently in any given week they would do exercise lasting at least 20 minutes and intensive enough to break a sweat.
And they were questioned about lifestyle, diet and recent stressful events, as these can all affect a person's immune system.
But the most significant factors that cut colds was how much exercise a person did and how fit they perceived themselves to be.
Feeling fit and being active cut the risk of having a cold by nearly 50%.
People who were physically active on five or more days of the week were unwell with a cold for about five days of the three-month period, compared to nine days for those who did little or no exercise.
And even when they were ill, they suffered less with their symptoms.
The severity of symptoms fell by 41% among those who felt the fittest and by 31% among those who were the most active.
Although these levels fall back within a few hours, each session is likely to provide an immune boost to fight off infections like the common cold.
Professor Steve Field, chairman of the Royal College of General Practitioners, said: "This is yet more evidence for doing exercise. It reflects what we have believed for some time.
"Exercise makes us feel better and now here's more evidence that it is good for us."
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