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16 November 2010

Green tea extracts plus vitamin D may boost bone health

Combining green tea polyphenols and a form of vitamin D called alfacalcidol may boost bone structure and strength, according to a new study in mice.

The new research in mice suggests that supplementation with either green tea polyphenols or alfacalcidol (1-alpha-OH-vitamin D3) may reverse damage to bones caused by lipopolysaccharide induced chronic inflammation, while combining the ingredients may sustain bone micro-architecture and strength, according to new findings published in The Journal of Nutritional Biochemistry.

According to the authors, led by Dr Chwan-Li Shen from Texas Tech University Health Sciences Center, the study also shows that the improvement in bone micro-architecture and quality along with the down-regulation bone TNF-alpha expression mechanism further corroborate the anti-inflammatory role of green tea polyphenols and 1-alpha-OH-vitamin D3 (alfacalcidol) in skeletal health – which may reduce the risk of osteoporosis.

Bone loss

Chronic inflammation has been associated with progression of bone loss and micro- architecture deterioration through oxidative stress and excessive production of pro-inflammatory molecules such as tumor necrosis factor-alpha (TNF-alpha).

Various anti-oxidant and anti-inflammatory compounds, such as green tea, alfacalcidol, and soy isoflavones have been suggested suppress TNF-alpha expression.

The researchers noted that certain compounds suggested to inhibit inflammation via suppressing TNF-alpha expression, may have therapeutic value in the prevention and treatment of chronic inflammation-induced bone loss.

In particular green tea (Camellia sinensis), has been suggested to have a wide range of effects on animal and human health due to its anti-oxidant and anti-inflammatory properties.

It has been reported in previous studies to have beneficial effects in various inflammatory conditions, such as inflammatory bowel disease, collagen-induced arthritis and lipopolysaccharide (LPS)-induced gingival inflammation.

The new study investigated the effects of green tea polyphenols and alfacalcidol on bone microstructure and strength along with possible mechanisms in rats with chronic inflammation.

Damage reversal

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