Combining green tea polyphenols and a form of vitamin D called alfacalcidol may boost bone structure and strength, according to a new study in mice.
The new research in mice suggests that supplementation with either green tea polyphenols or alfacalcidol (1-alpha-OH-vitamin D3) may reverse damage to bones caused by lipopolysaccharide induced chronic inflammation, while combining the ingredients may sustain bone micro-architecture and strength, according to new findings published in The Journal of Nutritional Biochemistry.
According to the authors, led by Dr Chwan-Li Shen from Texas Tech University Health Sciences Center, the study also shows that the improvement in bone micro-architecture and quality along with the down-regulation bone TNF-alpha expression mechanism further corroborate the anti-inflammatory role of green tea polyphenols and 1-alpha-OH-vitamin D3 (alfacalcidol) in skeletal health – which may reduce the risk of osteoporosis.
Chronic inflammation has been associated with progression of bone loss and micro- architecture deterioration through oxidative stress and excessive production of pro-inflammatory molecules such as tumor necrosis factor-alpha (TNF-alpha).
Various anti-oxidant and anti-inflammatory compounds, such as green tea, alfacalcidol, and soy isoflavones have been suggested suppress TNF-alpha expression.
The researchers noted that certain compounds suggested to inhibit inflammation via suppressing TNF-alpha expression, may have therapeutic value in the prevention and treatment of chronic inflammation-induced bone loss.
In particular green tea (Camellia sinensis), has been suggested to have a wide range of effects on animal and human health due to its anti-oxidant and anti-inflammatory properties.
It has been reported in previous studies to have beneficial effects in various inflammatory conditions, such as inflammatory bowel disease, collagen-induced arthritis and lipopolysaccharide (LPS)-induced gingival inflammation.
The new study investigated the effects of green tea polyphenols and alfacalcidol on bone microstructure and strength along with possible mechanisms in rats with chronic inflammation.