A new study on mice shows that a deficiency in folate, riboflavin, and vitamins B6 and B12 may increase the risk of DNA damage and colorectal cancers.
Researchers examined the Wnt pathway (a cellular signaling pathway linked to more than 85 per cent of colorectal cancers) and found that mild depletion of all four B vitamins was promoted the risk of tumor formation. Previous research suggested that folate deficiency alone increase the risk, but this new study suggests a more complex interaction.
However, some studies have reported that the B-vitamin may in fact increase the risk of colorectal cancer.
Colorectal cancer accounts for 9 per cent of cancer cases worldwide. The highest rate of incidence is in the industrialized world.
* NutraIngredients.com November 21, 2007