Cranberry Juice Shows Promise Blocking Staph Infections

ScienceDaily (Sep. 3, 2010) — Expanding their scope of study on the mechanisms of bacterial infection, researchers at Worcester Polytechnic Institute (WPI) have reported the surprise finding from a small clinical study that cranberry juice cocktail blocked a strain of Staphylococcus aureus (S. aureus) from beginning the process of infection.

The data was reported in a poster presentation at the American Chemical Society's national meeting in Boston on August 23, 2010, by Terri Camesano, professor of chemical engineering at WPI. "Most of our work with cranberry juice has been with E. coli and urinary tract infections, but we included Staphylococcus aureus in this study because it is a very serious health threat," Camesano said. "This is early data, but the results are surprising."

The virulent form of E. coli that Camesano studies is the primary cause of most urinary tract infections. Strains of S. aureus can cause a range of "staph infections" from minor skin rashes to serious bloodstream infections. One particular strain, known as Methicillin-resistant Staphylococcus aureus, or MRSA, is a growing public health problem in hospitals, nursing homes, and other institutions because it doesn't respond to most antibiotics.

To cause an infection, bacteria must first adhere to a host, then gather together in colonies to form a biofilm. In the current study, Camesano recruited healthy female students at WPI to drink either cranberry juice cocktail or a placebo fluid that looked and tasted like cranberry juice. The subjects provides urine samples at prescribed intervals after drinking the juice or placebo, and those samples were incubated in petri dishes with several strains of E. coli and a single strain of S. aureus. Camesano's team stained the bacteria with a special dye, then used a spectrophotometer to measure the density of the bacterial colonies in the dishes over time. Their analysis showed that the urine samples from subjects who had recently consumed cranberry juice cocktail significantly reduced the ability of E. coli and S. aureus to form biofilms on the surface of the dishes.

"What was surprising is that Staphylococcus aureus showed the most significant results in this study," Camesano said. "We saw essentially no biofilm in the staph samples, which is very surprising because Staph aureus is usually very good at forming biofilms. That's what makes it such a health problem."

With E. coli, Camesano's focal point is the small hair-like projections known as fimbriae, which act like hooks and help the bacteria latch onto cells that line the urinary tract. Camesano has shown that exposure to cranberry juice causes the fimbriae on E. coli to curl up, blunting their ability to attach to cells. S. aureous, however, doesn't have fimbirae, so there must be other reasons why the cranberry juice affected its biofilm formation in the study. "These results do create more questions than answers," Camesano said. "We believe this is an important new area to explore, and we are now thinking about how best to proceed."

Since bacterial adhesion is required for infection, Camesano hopes that better understanding of the specific mechanisms and forces involved in biofilm formation will help inform future studies aimed at identifying potential drug targets for new antibiotics. The data may also be useful in studies aimed at engineering the surfaces of invasive medical devices like catheters to make them more resistant to bacterial adhesion.

The research detailed in the current study was supported by grants from the Cranberry Institute and the Wisconsin Cranberry Board.

Broccoli 'boosts' healthy gut

Extracts of broccoli and banana may help in fighting stomach problems, research suggests.

Laboratory studies show fibres from the vegetables may boost the body's natural defences against stomach infections.

Trials are under way to see if they could be used as a medical food for patients with Crohn's disease.

Crohn's disease is an inflammatory bowel disease that causes symptoms such as diarrhoea and abdominal pain.

Scientists at the University of Liverpool looked at how roughage from vegetables influenced the passage of harmful bacteria through cells inside the gut.

They found that fibres from the plantain, a type of large banana, and broccoli, were particularly beneficial. But a common stabiliser added to processed foods during the manufacturing process had the opposite effect.

Dr Barry Campbell, from the University of Liverpool, said: "This research shows that different dietary components can have powerful effects on the movement of bacteria through the bowel.

"We have known for some time the general health benefits of eating plantain and broccoli, which are both high in vitamins and minerals, but until now we have not understood how they can boost the body's natural defences against infection common in Crohn's patients.

"Our work suggests that it might be important for patients with this condition to eat healthily and limit their intake of processed foods."

M-cells

The research, published in the journal Gut, and carried out in collaboration with experts in Sweden and Scotland, investigated special cells, called M-cells, which line the gut and ward off invading bacteria.

Work was carried out in laboratory-grown cells and tissue samples from patients undergoing surgery for stomach problems.

Clinical trials are now underway in 76 Crohn's patients to find out whether a medical food containing plantain fibres could help keep the disease at bay.

"It may be that it makes sense for sufferers of Crohn's to take supplements of these fibres to help prevent relapse," said Professor Jon Rhodes of the University of Liverpool.

Commenting on the study, a spokesperson for Crohn's and Colitis, which represents patients with inflammatory bowel disorders, welcomed further insight into how the gut combats bacteria like E.Coli.

"Knowledge of the M-cell role offers a more detailed explanation as to why a healthy diet can improve the health and well being for people with Crohn's disease and healthy individuals alike," she said.

Andy Roddick Rolls, Holds Court on Heat, Blake, Scoliosis

NEW YORK -- Andy Roddick enjoyed a relatively easy first-round match on Monday at the U.S. Open, defeating Stephane Robert of France 6-3, 6-2, 6-2. Roddick, the No. 9 seed, lost his serve only once and broke Robert in half of his 12 service games. Completing the match in one hour and 42 minutes was important for Roddick, who recently suffered through a battle of mononucleosis.

On his health, Roddick said, "It's going the right way. To be honest, once you decide to play, I think you throw all the excuses and everything else out the window. If I decide to play, then it's up to me to give 100 percent of what I have. So it's not something I really want to discuss too much from this point forward. I'm not going to analyze it every day."

Like most Roddick press conferences, his meeting with the media after his victory over Robert covered subjects beyond his own tennis game.

Roddick, a longtime Miami Heat fan, was asked about his team's acquisition of free agents LeBron James and Chris Bosh.

"I'm sick of defending my fanhood," said Roddick. "I was going to the games in '01, when they were paying people to come. I was in Boca (Raton) for a long time and went to four or five home games a year. I'm excited.

"I was just hoping and praying they'd re-sign Dwayne (Wade). Then when Bosh came, I was ecstatic. Then when LeBron came it was bordering on ridiculous. Like everyone else, I'm excited to see how it all goes together."

Roddick's passion for Miami's basketball team, however, is dwarfed by his admiration for Davis Cup teammate James Blake, who was honored during Monday night's opening ceremonies for overcoming scoliosis to become a top player.

"I'm extremely biased," said Roddick. "I'm a massive James Blake fan. His career is one thing, but I also like his character. I like the way he goes about his business. He's been a real good friend to me."

Blake, a wild-card entry in this year's Open, has struggled of late, but is hopeful for another memorable run.

Said Roddick: "My biggest hope for James is that he can get healthy enough to have a run that he would like."

Dark chocolate bits may protect women against heart failure

Eating a small amount of high-quality dark chocolate one to three times a month may help stave off heart failure in women, a new Harvard study suggests.
But if you ingest too much "good" chocolate, that protective effect goes away, according to the researchers who report their finding in the Aug. 17 issue of Circulation: Heart Failure.

"Up until now, (researchers) were focused on other outcomes, such as the effects on blood pressure and other things," he explained.

And those studies did find that moderate amounts of chocolate do seem to lower blood pressure.

"The beneficial effects on blood pressure are likely an important part of the mechanisms of what we're observing," said Mittleman, who is director of the Cardiovascular Epidemiology Research Unit at Beth Israel Deaconess Medical Center at Harvard Medical School in Boston.

The study authors studied the chocolate-eating habits of 31,823 Swedish women, aged 48 to 83, reported over a period of nine years.

Women who ate one to three servings of chocolate (20 to 30 grams) a month had a 32% reduced risk of heart failure, compared to women who did not eat the sweet regularly. More chocolate than that (one to two servings a week), and the benefit disappeared, while much more than that (three to six servings a week), and the risk actually increased by 23%.

"Chocolate is still very calorie-dense, and there's fat and sugar that comes along with it, so moderation is a very important part of the story," Mittleman said.

Chocolate in Sweden is held to different quality standards than in the United States, but there are still characteristics one should look for when choosing chocolate, Mittleman said.

The chocolate measured in this study was mostly high-quality dark chocolate without a lot of added sugar, though it was commercially available, he said.

And the higher the cocoa content, the better. The cocoa content of the chocolate consumed by the women in this study was about 30% whereas, in the United States, dark chocolate is only required to contain 15% cocoa solids.

And 20 to 30 grams would be about half-to-two-thirds of an average American candy bar, Mittleman said.

The heart benefit of dark chocolate could be the result of any number of factors, including more flavanoids, or antioxidants, that can smooth heart function.

Mittleman said there's no reason that the benefits of chocolate wouldn't extend to men as well, but this still needs to be confirmed.

Linda Van Horn, immediate past chair of the American Heart Association's Nutrition Committee and professor in the Department of Preventive Medicine at Northwestern University's Feinberg School of Medicine in Chicago, said people shouldn't misinterpret the study findings as a carte blanche to satisfy their sweet tooth.

"This is not an 'eat all you want' take-home message, rather it's that eating a little dark chocolate can be healthful, as long as other adverse behaviors do not occur, such as weight gain or excessive intake of non-nutrient dense 'empty' calories," she said in a news release issued by the American Heart Association.

Interestingly, an Australian study released last week found that patients would actually prefer taking a pill than chocolate when it comes to controlling blood pressure.

Green leafy veg 'may cut diabetes risk'

A diet rich in green leafy vegetables may reduce the risk of developing diabetes, UK research says.

In an analysis of six studies into fruit and vegetable intake, only food including spinach and cabbage was found to have a significant positive effect.

A portion and a half a day was found to cut type 2 diabetes risk by 14%, the British Medical Journal (BMJ) reports.

But experts urged people to continue to aim for five portions of fruit and vegetables a day.

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This study suggests that green leafy vegetables seem to be particularly important in terms of preventing diabetes”
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Professor Melanie Davies

University of Leicester
The researchers from Leicester University reviewed data from the studies of 220,000 adults in total.

They found that eating more fruit and vegetables in general was not strongly linked with a smaller chance of developing type 2 diabetes but "there was a general trend in that direction".

Yet when it came to green leafy vegetables, which the researchers said also includes broccoli and cauliflower, the risk reduction was significant.

The team calculated that a daily dose of 106g reduced the risk of diabetes by 14% - a UK "portion" is classed as 80g.

It is not clear why green leafy vegetables may have a protective effect but one reason may be they are high in antioxidants, such as vitamin C and another theory is that they contain high levels of magnesium.

Study leader Professor Melanie Davies, professor of diabetic medicine at the University of Leicester, said the message to eat five portions of fruit and vegetables a day remains an important one.

But she added: "People like very specific health messages.

"We know that intake of fruit and vegetables is important, but this study suggests that green leafy vegetables seem to be particularly important in terms of preventing diabetes."

The team are now planning a study in people at high risk of developing the condition to see if increasing their intake of vegetables like spinach and kale can help to reduce their chances of being diagnosed with diabetes.

Fruit and veg

In 2008/09, the National Diet Nutrition Survey showed that, although fruit and vegetable intake has risen over the past decade, only a third of men and women eat the recommended five-a-day.

In an accompanying editorial in the BMJ, Professor Jim Mann from the University of Otago in New Zealand, stressed that the message of increasing overall fruit and vegetable intake must not be lost "in a plethora of magic bullets," even though green leafy vegetables clearly can be included as one of the daily portions.

Dr Iain Frame, director of research at Diabetes UK said: "We already know that the health benefits of eating vegetables are far-reaching but this is the first time that there has been a suggested link specifically between green leafy vegetables and a reduced risk of developing type 2 diabetes."

But he warned the evidence was limited and it was too early to isolate green leafy vegetables and present them alone as a method to cut the chances of developing the condition.

"We would be concerned if focusing on certain foods detracted from the advice to eat five portions of fruits and vegetables a day, which has benefits in terms of reducing heart disease, stroke, some cancers and obesity as well as type 2 diabetes."

Diabetes UK is currently funding research into whether fermentable carbohydrates found in foods such as asparagus, garlic, chicory and Jerusalem artichokes could help weight loss and prevent Type 2 diabetes.

A Joint Venture

70 million. That’s the number of Americans with joint issues, but that number is expected to jump even higher as Baby Boomers age. Estimates indicate that by the year 2030, 40% of American adults will have unhealthy joints.
That could mean a lot of discomfort—for joints and for pocketbooks, too. Currently, joint unhealth tops more than $128 billion a year in lost earnings and in medical care.
The truth is that our body, particularly our joints, will tell us when it’s had enough—no matter if it’s from lugging kids around or gardening in your backyard. The cause doesn’t matter so much. Your body sure feels it, though!
In order to lessen the occurrence of these joint episodes, you need to be aware of what Dale Anderson, M.D., calls your “trouble zones.” Anderson is the coordinator of the Minnesota Act Now Project in Minneapolis and the author of Muscle Pain Relief in 90 Seconds.

Walking to School Could Reduce Stress Reactivity in Children, May Curb Risk of Heart Disease

A simple morning walk to school could reduce stress reactivity in children during the school day, curbing increases in heart rate and blood pressure that can lead to cardiovascular disease later in life, according to a new University at Buffalo study.

UB researchers report in the August 2010 issue of Medicine & Science in Sports & Exercise that children who took a simulated walk to school later experienced smaller elevations in systolic blood pressure, heart rate and perceived stress while taking a short exam than children who had gotten a simulated ride to school.

Cardiovascular reactivity -- including changes in heart rate and blood pressure due to stress -- is associated with the beginnings of cardiovascular disease in children, and atherosclerosis -- the dangerous build-up of cholesterol, calcium, fat and other substances in artery walls -- in adults.

"The cardiovascular disease process begins in childhood, so if we can find some way of stopping or slowing that process, that would provide an important health benefit," says James Roemmich, UB associate professor of pediatrics and exercise and nutrition science and senior investigator on the study, which he completed with graduate students Maya Lambiase and Heather Barry. "We know that physical activity has a protective effect on the development of cardiovascular disease, and one way it may be doing so is by reducing stress reactivity."

Roemmich says because it's not known how long the protective effect of a bout of exercise lasts, parents and educators should promote active play time throughout the day.

"If it only lasts a couple of hours, then it would be most beneficial if a child walked or biked to school, then had recess during school, as well as a break at lunch, so they had opportunities for physical activity throughout the day," Roemmich says. "This would put them in a constantly protective state against stressors that they're incurring during the school day, whether that be taking an exam, trying to fit in with peers or speaking in front of classmates."

Roemmich says his study is the first to show that moderate-intensity exercise can reduce children's cardiovascular reactivity during later, stressful activities. The research builds on his earlier work, which demonstrated that higher-intensity interval exercise could afford similar protection in children.

In the more recent investigation, Roemmich and his team examined a group of 20 boys and 20 girls, all Caucasian and ages 10-14. All visited the Behavioral Medicine Research Laboratory in the morning. To simulate a ride to school, half sat in a comfortable chair and watched a 10-minute slide show of images of a suburban neighborhood, ending with an image of a suburban school. The other half performed a one-mile walk on a treadmill at a self-selected pace, wearing a book bag containing 10 percent of their body weight. As they walked, the images of the suburban neighborhood were projected onto a screen.

Following a 20-minute rest period after completing the passive and active commutes, all children took a Stroop test, which asks subjects to correctly identify the color of color names printed in the wrong color (the word "green" printed in blue ink, for instance). On average, during this activity, heart rate increased by about three beats per minute in children who walked, compared with about 11 beats per minute in children who "rode" to school. Similarly, the rise in systolic blood pressure was more than three times higher, and the change in perceived stress about twice as high, for the passive commuters.

"The perception of a stressor as a threat is the beginning of the stress reactivity process, so if you can dampen that initial perception, then you reduce the magnitude of the fight-or-flight response," Roemmich says. "This results in lower heart rate and blood pressure responses to the stressor. Exercise helped dampen even the initial response."

Chronic pain can be 'paralyzing' for women

(CNN) -- The sensation began in Melanie Thernstrom's neck the same day she went for a long swim. It flowed down through her right shoulder to her hand, as if she had a blistering sunburn underneath her skin.

Thernstrom, 32 at the time, had a couple of doctor's appointments about it, but went along with a neurologist's suggestion that it would get better on its own.

"I felt increasingly worried, but somehow not in a way that enabled me to take further action, more in a way that paralyzed me," she said. "I think of pain like one of those sea animals that attacks you by paralyzing you first."

She's now 46, the mother of 9-month-old twins, and still dealing with the pain.

Around the world, chronic pain affects a larger proportion of women than men, said Jennifer Kelly of the Atlanta Center for Behavioral Medicine in Georgia. Doctors are finding that women have more recurrent pain and more disabilities from pain than men, she said. Kelly spoke at the convention of the American Psychological Association in San Diego, California, on Thursday.

Women's chronic pain also tends to be more intense and last longer than men's, she said. Pain-causing illnesses such as fibromyalgia, rheumatoid arthritis and irritable bowel syndrome are all more common in women than men, according to the International Association for the Study of Pain.

One possible reason that women bear this burden of pain is hormones, Kelly said. The menstrual cycle can be associated with changes in discomfort among women with chronic pain.

Pain also can have long-lasting consequences that scientists are just beginning to understand. A study in the September issue of the journal PAIN found that women who suffer menstrual cramps have significant brain structure changes compared with women who don't.. Other studies have also found abnormal brain structure changes in people with disorders such as chronic back pain and irritable bowel syndrome. Scientists do not yet know what these changes mean, or if they are reversible.

A 2008 study in the Journal of Neuroscience found that people with chronic pain have neurons firing too much in certain brain regions, which could lead to permanent damage. This may explain the repeated findings in other studies that chronic pain is linked to depression.

Women tend to focus on emotional aspects of pain, worrying about how it will affect their responsibilities, whereas men focus on the sensory aspect, Kelly said. That's why it is especially important for physicians to help women challenge their negative thoughts that make the situation worse, she said.

Thernstrom, who eventually found that she suffers from overlapping arthritic conditions, agrees that many patients with chronic pain need help changing their mind set about pain. She spent a long time feeling angry and frustrated because she was looking for a "magical cure," and despaired when interventions such as physical therapy and medications did not deliver complete, quick solutions.

"Part of what helped me was switching out the model in which I had to be pain free to be happy," Thernstrom said. "Realizing I can have some pain, just like it can be raining outside and I can be happy -- it's all a matter of what level the pain is at."

Despite men and women dealing with pain differently, doctors treat them the same for conditions such as rheumatoid arthritis, said Dr. Chaim Putterman, chief of rheumatology at Montefiore Medical Center and Albert Einstein College of Medicine in the Bronx, New York.

"We may be doing our patients a disservice by doing it that way, and perhaps there are gender-specific influences that need to be taken into account that we're not taking into account," he said.

Psychological counseling for people with chronic pain can help patients reframe how they see their pain and manage the consequences in other areas of their lives, Kelly said.

Many studies have found a connection between depression and chronic pain, with mental stress exacerbating physical discomfort and vice versa. Depression screening should be part of any evaluation of a patient with chronic pain, Putterman said.

Some of the symptoms of fibromyalgia are akin to depression, and medications for the chronic pain condition also work as antidepressants, Putterman said. Cognitive behavioral therapy, which helps people change their thinking and behavior patterns, has also been shown to be effective for this condition.

But some chronic pain patients are resistant to mental health referrals and want treatment only for the pain itself, he said.

"You would prefer to have an organic disease than a mental disease because of the stigma that's associated with mental disease in many circles," he said.

In general, women are more dependent on their network of friends and family in dealing with chronic pain than men, who tend to handle issues more by themselves, Putterman said. In his experience, women tend to come to doctor's appointments with members of their family, whereas men tend to go alone.

Thernstrom's new book "The Pain Chronicles," on sale Tuesday, details her own journey through pain as well as a history of pain from ancient Babylon to the present. For her research for the book, she observed doctors consulting with hundreds of patients of chronic pain and then followed some of those patients for eight years as they struggled to overcome their constant discomfort.

Today, her pain interferes with her ability to pick up her children as much as she'd like; she wishes she could carry them around in a sling, for instance, but already she needs a baby sitter's help to take the twins around.

Seeking treatment for pain as early as possible is crucial, she said.

"Pain is like water damage to your house after the house collapses," pain specialist Dr. Daniel Carr told Thernstrom for her book. Thernstrom herself adds, "The time to fix it is when it's a drip."

Liang Zao Bao Newspaper Interview Aug 2010

Pushing back on back surgery: Insurers, and some physicians, are questioning the need for aggressive spinal surgery

August 9th, 10 - Star Tribune

Three years ago, Amy Leyden took her 10-year-old son, Luke, on a vacation to Oregon. Her back hasn't been the same since.

In a furious game of touch football, Leyden made a spectacular catch but landed flat on her back. That night, she slept on a friend's couch, and the next day, the fearless duo went on an ill-advised dune buggy ride on the Oregon coast.